Zepp Health (ZEPP) had the highest return last year by a small-cap US stock, returning 936.2%.

ASSET	YEAR	% RETURN
Zepp Health (ZEPP)	2025	936.15%
Relmada Therapeutics (RLMD)	2025	830.99%
Palvella Therapeutics (PVLA)	2025	801.55%
DeFi Development (DFDV)	2025	650.48%
Nanobiotix (NBTX)	2025	643.41%
AXT (AXTI)	2025	636.49%
Avino Silver & Gold Mines (ASM)	2025	582.42%
Newegg Commerce (NEGG)	2025	534.5%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	515.33%
Almonty Industries Inc Common Shares (ALM)	2025	511.81%
Aimei Health Technology Co, Ltd Ordinary Share (AFJK)	2025	501.03%
DBV Technologies (DBVT)	2025	482.67%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	2025	471.67%
Invivyd (IVVD)	2025	425.53%
Inhibrx Biosciences (INBX)	2025	416%
Nutex Health (NUTX)	2025	413.96%
IsoEnergy (ISOU)	2025	386.63%
Village Farms International (VFF)	2025	370.36%
Integra Resources (ITRG)	2025	355.68%
ThredUp (TDUP)	2025	343.75%
Zenas BioPharma, Inc Common Stock (ZBIO)	2025	339.59%
Sify Technologies (SIFY)	2025	326.22%
CytomX Therapeutics (CTMX)	2025	321.78%
Alto Neuroscience (ANRO)	2025	313.95%
Ventyx Biosciences (VTYX)	2025	306.76%

Small-cap stocks are treated as having a market cap between $300M and $2B.