Santech (STEC) had the highest return last year by a US stock, returning 31,856.1%.

ASSET	YEAR	% RETURN
Santech (STEC)	2025	31,856.14%
Regencell Bioscience (RGC)	2025	15,618.56%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Abivax SA American Depositary Shares (ABVX)	2025	1,762.64%
Terrestrial Energy (IMSRW)	2025	1,727.59%
FiEE (FIEE)	2025	1,372.48%
NovaBay Pharmaceuticals (NBY)	2025	1,346.15%
Oncology Institute (TOI)	2025	1,063.4%
New Era Energy & Digital (NUAIW)	2025	1,023.42%
Hycroft Mining (HYMC)	2025	951.77%
Zepp Health (ZEPP)	2025	936.15%
Relmada Therapeutics (RLMD)	2025	830.99%
XMax (XWIN)	2025	809.09%
Palvella Therapeutics (PVLA)	2025	801.55%
Cidara Therapeutics (CDTX)	2025	714.79%
Abits (ABTS)	2025	707.21%
Diginex Limited Ordinary Shares (DGNX)	2025	683.1%
Celcuity LLC (CELC)	2025	654.46%
DeFi Development (DFDV)	2025	650.48%
Nanobiotix (NBTX)	2025	643.41%
AXT (AXTI)	2025	636.49%
Terns Pharmaceuticals (TERN)	2025	616.31%
Haoxi Health Technology Limited Class A Ordinary Shares (HAO)	2025	593.9%
Avino Silver & Gold Mines (ASM)	2025	582.42%
Sandisk (SNDK)	2025	577.07%