Amerant Bancorp (AMTB) had the highest return between 2015 and 2021 by a US stock, returning 10,854,266.7%.

ASSET	YEARS	% RETURN
Amerant Bancorp (AMTB)	2015-2021	10,854,266.67%
Helport AI Limited Ordinary Shares (HPAI)	2015-2021	9,759,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2015-2021	6,234,046.34%
KULR Technology (KULR)	2015-2021	5,519,900%
DarioHealth (DRIO)	2015-2021	3,325,541.03%
GreenPower Motor (GP)	2015-2021	2,633,233.33%
MDxHealth SA ADR (MDXH)	2015-2021	1,586,566.67%
Blackboxstocks (BLBX)	2015-2021	839,900%
MicroCloud Hologram (HOLO)	2015-2021	577,362.44%
Eastside Distilling (BLNE)	2015-2021	536,631.63%
TNF Pharmaceuticals (TNFA)	2015-2021	453,458.92%
Integra Resources (ITRG)	2015-2021	429,900%
Weatherford International (WFRD)	2015-2021	353,101.3%
Immatics (IMTX)	2015-2021	268,700%
GT Biopharma (GTBP)	2015-2021	261,328.57%
Bone Biologics (BBLG)	2015-2021	123,529.26%
FingerMotion (FNGR)	2015-2021	56,780%
Freedom (FRHC)	2015-2021	55,364%
Diversified Energy (DEC)	2015-2021	43,200%
Applied Digital (APLD)	2015-2021	43,095.88%
GeoVax Labs (GOVX)	2015-2021	36,221.07%
AquaBounty Technologies (AQB)	2015-2021	29,066.67%
eXp World (EXPI)	2015-2021	22,774.12%
Alarum Technologies (ALAR)	2015-2021	20,843.95%
SurgePays (SURG)	2015-2021	20,100%