SS Innovations International Inc Common Stock (SSII) had the highest return in 2022 by a US stock with a market cap of $1B+, returning 126,150%.

ASSET	YEAR	% RETURN
SS Innovations International Inc Common Stock (SSII)	2022	126,150%
Indivior PLC Ordinary Shares (INDV)	2022	520.37%
Scorpio Tankers (STNG)	2022	315.75%
Torm PLC Class A (TRMD)	2022	294.68%
Verona Pharma PLC ADR (VRNA)	2022	284.83%
Tidewater (TDW)	2022	244.39%
Madrigal Pharmaceuticals (MDGL)	2022	238.09%
TransMedics (TMDX)	2022	221.29%
PBF Energy (PBF)	2022	211.45%
Vista Oil Gas ADR (VIST)	2022	195.47%
Rhythm Pharmaceuticals (RYTM)	2022	191.2%
Teekay Tankers (TNK)	2022	177.32%
ADMA Biologics (ADMA)	2022	177.14%
Catalyst Pharmaceuticals (CPRX)	2022	173.93%
Transportadora de Gas del Sur SA ADR (TGS)	2022	163.98%
International Seaways (INSW)	2022	159%
Akero Therapeutics (AKRO)	2022	157.64%
Ardelyx (ARDX)	2022	154.46%
Peabody Energy (BTU)	2022	153.79%
Alpha Metallurgical Resources (AMR)	2022	148.63%
Belite Bio Inc ADR (BLTE)	2022	141.16%
YPF Sociedad Anonima (YPF)	2022	138.7%
Biohaven Pharmaceutical (BHVN)	2022	131.33%
Constellation Energy (CEG)	2022	128.92%
Wave Life Sciences (WVE)	2022	123.64%