Dollar Tree (DLTR) had the highest return between 2008 and 2011 by a large-cap US stock, returning 381%.

ASSET	YEARS	% RETURN
Dollar Tree (DLTR)	2008-2011	380.96%
Booking (BKNG)	2008-2011	300.61%
Tractor Supply (TSCO)	2008-2011	299.14%
Flutter Entertainment (FLUT)	2008-2011	291.07%
Ross Stores (ROST)	2008-2011	290.92%
Ulta Beauty (ULTA)	2008-2011	281.88%
F5 Networks (FFIV)	2008-2011	278.73%
First Majestic Silver (AG)	2008-2011	250.1%
Edwards Lifesciences (EW)	2008-2011	209.27%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2011	202.46%
Alamos Gold (AGI)	2008-2011	198.54%
Nova (NVMI)	2008-2011	195.98%
Baidu (BIDU)	2008-2011	195.23%
XPO Logistics (XPO)	2008-2011	180.7%
Estee Lauder Companies (EL)	2008-2011	171.38%
AutoZone (AZO)	2008-2011	170.58%
Old Dominion Freight Line (ODFL)	2008-2011	167.82%
Netflix (NFLX)	2008-2011	160.91%
Jazz Pharmaceuticals (JAZZ)	2008-2011	158.91%
Franco-Nevada (FNV)	2008-2011	158.23%
Domino's Pizza Inc Common Stock (DPZ)	2008-2011	156.81%
Fortinet (FTNT)	2008-2011	156.59%
Transdigm (TDG)	2008-2011	150.5%
Ambev SA ADR (ABEV)	2008-2011	150.3%
Clean Harbors (CLH)	2008-2011	148.22%

Large-cap stocks are treated as having a market cap of $10B+.