Regencell Bioscience (RGC) has had the highest return this year by a US stock, returning 9,480.8%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	9,480.84%
CannBioRx Life Sciences (ATNFW)	2025	4,287.76%
DeFi Development (DFDV)	2025	2,903.42%
WW International, Inc Common Stock (WW)	2025	2,300%
HCM II Acquisition (HONDW)	2025	2,037.93%
Oncology Institute (TOIIW)	2025	1,804.76%
Blue Gold Limited Warrant (BGLWW)	2025	1,800%
Zepp Health (ZEPP)	2025	1,439.23%
Diginex Limited Ordinary Shares (DGNX)	2025	1,258.92%
CEA Industries (BNCWW)	2025	1,242.28%
FiEE (FIEE)	2025	1,193.58%
Newegg Commerce (NEGG)	2025	1,159.38%
Oncology Institute (TOI)	2025	1,138.56%
CEA Industries (VAPEW)	2025	1,108.05%
K Wave Media (KWMWW)	2025	1,063.11%
USA Rare Earth (USARW)	2025	1,048%
Protagenic Therapeutics (PTIXW)	2025	992.31%
Abivax SA American Depositary Shares (ABVX)	2025	967.4%
Webull Corporation Warrants (BULLW)	2025	952.54%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	922.22%
Cohen Circle Acquisition Corp I Warrant (CCIRW)	2025	885.29%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	2025	847.91%
Ainos (AIMDW)	2025	835.09%
Global Interactive Technologies (GITS)	2025	808.71%
CID HoldCo, Inc Warrants (DAICW)	2025	785%