QXO (QXO) had the highest return between 2010 and 2022 by a US stock, returning 4,685,225%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2022	4,685,225%
BioNexus Gene Lab Corp Common stock (BGLC)	2010-2022	2,780,387.8%
KULR Technology (KULR)	2010-2022	2,399,900%
Nutex Health (NUTX)	2010-2022	1,899,900%
GeoVax Labs (GOVX)	2010-2022	1,243,321.05%
MDxHealth SA ADR (MDXH)	2010-2022	1,101,566.67%
Sequans Communications (SQNS)	2010-2022	999,900%
Connexa Sports Technologies (YYAI)	2010-2022	467,900%
Heart Test Laboratories Inc Common Stock (HSCS)	2010-2022	246,958.82%
AquaBounty Technologies (AQB)	2010-2022	212,122.22%
Immatics (IMTX)	2010-2022	174,100%
Xpel (XPEL)	2010-2022	157,952.63%
Iqstel (IQST)	2010-2022	146,895.96%
Eastside Distilling (BLNE)	2010-2022	137,437.54%
Integra Resources (ITRG)	2010-2022	126,500%
Aurora Cannabis (ACB)	2010-2022	122,966.67%
Blackboxstocks (BLBX)	2010-2022	70,488.24%
Applied Digital (APLD)	2010-2022	59,254.84%
OrganiGram (OGI)	2010-2022	42,005.26%
INVO Fertility (IVF)	2010-2022	40,068.42%
TCTM Kids IT Education (VSA)	2010-2022	30,555.11%
Processa Pharmaceuticals (PCSA)	2010-2022	26,090.48%
Guardforce AI (GFAI)	2010-2022	24,323.08%
FingerMotion (FNGR)	2010-2022	22,380%
Cementos Pacasmayo SAA ADR (CPAC)	2010-2022	13,000.67%