MDxHealth SA ADR (MDXH) has had the highest return since 2021 by a US stock, returning 328,990.9%.

ASSET	% RETURN
MDxHealth SA ADR (MDXH)	328,990.91%
Everbright Digital Holding Limited Ordinary Shares (EDHL)	309,900%
DevvStream Corp Common Stock (DEVS)	93,860%
BioNexus Gene Lab Corp Common stock (BGLC)	84,247.83%
Castellum (CTM)	19,663.64%
MKDWELL Tech Inc Ordinary Share (MKDW)	17,310.71%
Applied Digital (APLD)	16,553.33%
Mingteng International Corporation Inc Ordinary Shares (MTEN)	10,585.71%
Heart Test Laboratories Inc Common Stock (HSCS)	9,194.12%
Regencell Bioscience (RGC)	8,348.39%
VS Media Holdings Limited Class A Ordinary Shares (VSME)	5,054.06%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
TechCreate (TCGL)	3,740.89%
Celestica (CLS)	3,555.58%
Azitra (AZTR)	3,487.5%
Synergy CHC Corp Common Stock (SNYR)	3,202.06%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	3,192.18%
Power Solutions International, Inc Common Stock (PSIX)	2,485.76%
Comfort Systems USA (FIX)	2,364.49%
Profusa, Inc Common Stock (PFSA)	2,216.6%
Sterling Construction (STRL)	2,122.64%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2,080.56%
Vista Oil Gas ADR (VIST)	2,057.14%
Lottery (SEGG)	2,048.76%
Guardforce AI (GFAI)	2,038.94%