Sandisk (SNDK) has had the highest return between 2025 and 2026 by a mega-cap US stock, returning 4,335.2%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	4,335.23%
Micron Technology (MU)	2025-2026	1,031.86%
Dell Technologies (DELL)	2025-2026	360.34%
Intel (INTC)	2025-2026	353.14%
Lam Research (LRCX)	2025-2026	306.96%
Advanced Micro Devices (AMD)	2025-2026	273.01%
Banco Santander SA ADR (SAN)	2025-2026	249.92%
GE Vernova LLC (GEV)	2025-2026	184%
KLA (KLAC)	2025-2026	175.83%
Applied Materials (AMAT)	2025-2026	168.65%
Crowdstrike (CRWD)	2025-2026	148.15%
Toronto Dominion Bank (TD)	2025-2026	147.93%
Palantir Technologies (PLTR)	2025-2026	139.54%
HSBC Holdings PLC ADR (HSBC)	2025-2026	139.13%
ASML Holding NV ADR (ASML)	2025-2026	136.75%
Amphenol (APH)	2025-2026	136.61%
Caterpillar (CAT)	2025-2026	123.61%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2025-2026	115.31%
Taiwan Semiconductor Manufacturing (TSM)	2025-2026	114.98%
Citigroup (C)	2025-2026	103.15%
Johnson & Johnson (JNJ)	2025-2026	100.78%
GE Aerospace (GE)	2025-2026	100.27%
BHP (BHP)	2025-2026	100.16%
Arm Holdings plc American Depositary Shares (ARM)	2025-2026	94.08%
Cisco Systems (CSCO)	2025-2026	90.71%

Mega-cap stocks are treated as having a market cap of $200B+.