Sitio Royalties (STR) had the highest return between 2017 and 2021 by a US stock, returning 14,251,900%.

ASSET	YEARS	% RETURN
Sitio Royalties (STR)	2017-2021	14,251,900%
BioNexus Gene Lab Corp Common stock (BGLC)	2017-2021	6,234,046.34%
KULR Technology (KULR)	2017-2021	5,519,900%
MDxHealth SA ADR (MDXH)	2017-2021	1,903,900%
Avalon GloboCare (ALBT)	2017-2021	736,426.95%
MicroCloud Hologram (HOLO)	2017-2021	577,362.44%
Integra Resources (ITRG)	2017-2021	429,900%
Immatics (IMTX)	2017-2021	268,700%
Freedom (FRHC)	2017-2021	50,321.82%
Applied Digital (APLD)	2017-2021	41,800%
AquaBounty Technologies (AQB)	2017-2021	29,066.67%
Alarum Technologies (ALAR)	2017-2021	20,843.95%
Enphase Energy (ENPH)	2017-2021	17,835.29%
FingerMotion (FNGR)	2017-2021	14,120%
Kaival Brands Innovations (KAVL)	2017-2021	12,321.67%
ABOT (ABOT)	2017-2021	11,308.51%
Digital Turbine (APPS)	2017-2021	8,612.86%
FitLife Brands, Inc Common Stock (FTLF)	2017-2021	6,639.68%
Semler Scientific (SMLR)	2017-2021	5,969.54%
Inotiv (NOTV)	2017-2021	5,225.32%
Xpel (XPEL)	2017-2021	4,777.14%
Arrowhead Pharmaceuticals (ARWR)	2017-2021	4,150%
Nuvve (NVVEW)	2017-2021	3,583.33%
Firefly Neuroscience (AIFF)	2017-2021	3,435.71%
HIVE Blockchain Technologies (HIVE)	2017-2021	3,288.96%