InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2023 by a US stock, returning 88,379,500%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2023	88,379,500%
Sitio Royalties (STR)	2003-2023	20,747,000%
Amerant Bancorp (AMTB)	2003-2023	7,953,100%
National Grid PLC ADR (NGG)	2003-2023	3,654,675%
Azitra (AZTR)	2003-2023	3,285,614.29%
Ferguson (FERG)	2003-2023	1,680,731.25%
Northern Oil & Gas (NOG)	2003-2023	1,322,730.77%
Brera Holdings PLC Class B Ordinary Shares (BREA)	2003-2023	1,311,900%
Inventrust Properties (IVT)	2003-2023	1,204,065%
Natwest (NWG)	2003-2023	836,483.33%
QVC (QVCGA)	2003-2023	814,714.81%
QXO (QXO)	2003-2023	814,429.29%
Nauticus Robotics (KITT)	2003-2023	729,492.03%
MDxHealth SA ADR (MDXH)	2003-2023	437,677.78%
KULR Technology (KULR)	2003-2023	379,900%
Integra Resources (ITRG)	2003-2023	211,900%
Immatics (IMTX)	2003-2023	210,500%
NioCorp Developments Ltd Common Stock (NB)	2003-2023	187,547.06%
Blackboxstocks (BLBX)	2003-2023	165,782.35%
Perspective Therapeutics (CATX)	2003-2023	133,233.33%
Monster Beverage (MNST)	2003-2023	131,130.07%
BioNexus Gene Lab Corp Common stock (BGLC)	2003-2023	129,168.29%