Cisco Systems (CSCO) had the highest return between 1993 and 1999 by a mega-cap US stock, returning 4,797.4%.

ASSET	YEARS	% RETURN
Cisco Systems (CSCO)	1993-1999	4,797.39%
Oracle (ORCL)	1993-1999	3,916.18%
Amazon (AMZN)	1993-1999	3,022.48%
Microsoft (MSFT)	1993-1999	2,097.54%
ASML Holding NV ADR (ASML)	1993-1999	1,922.25%
International Business Machines (IBM)	1993-1999	813.31%
GE Aerospace (GE)	1993-1999	739.91%
Home Depot (HD)	1993-1999	523.81%
Eli Lilly and (LLY)	1993-1999	425.35%
JPMorgan Chase (JPM)	1993-1999	414.67%
AstraZeneca PLC ADR (AZN)	1993-1999	386.44%
Berkshire Hathaway (BRK.A)	1993-1999	378.46%
Procter & Gamble (PG)	1993-1999	362.14%
Walmart (WMT)	1993-1999	350.83%
Wells Fargo (WFC)	1993-1999	346.7%
Toyota Motor Corporation ADR (TM)	1993-1999	337.33%
Johnson & Johnson (JNJ)	1993-1999	271.14%
Costco Wholesale (COST)	1993-1999	268.69%
Merck (MRK)	1993-1999	259.88%
McDonald’s (MCD)	1993-1999	245.44%
LIN TV (LIN)	1993-1999	229.4%
Taiwan Semiconductor Manufacturing (TSM)	1993-1999	223.46%
Chevron (CVX)	1993-1999	217.7%
Novo Nordisk A-S (NVO)	1993-1999	207.67%
Coca-Cola (KO)	1993-1999	203.09%

Mega-cap stocks are treated as having a market cap of $200B+.