Regencell Bioscience (RGC) has had the highest return this year by a US stock, returning 28,350.6%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	28,350.6%
Kindly MD, Inc Warrants (KDLYW)	2025	9,775%
Kindly (NAKAW)	2025	5,218.75%
DeFi Development (DFDV)	2025	3,597.43%
HCM II Acquisition (HONDW)	2025	1,986.21%
SRM Entertainment, Inc Common Stock (SRM)	2025	1,669.8%
M3-Brigade Acquisition V Corp Warrant (MBAVW)	2025	1,367.51%
TMC the metals company Inc Warrants (TMCWW)	2025	1,277.36%
K Wave Media (KWMWW)	2025	1,192.23%
Kindly MD, Inc Common Stock (KDLY)	2025	1,047.58%
Kindly (NAKA)	2025	1,046.77%
Asset Entities Inc Class B Common Stock (ASST)	2025	958%
Diginex Limited Ordinary Shares (DGNX)	2025	956.34%
Columbus Circle Capital Corp I Warrant (CCCMW)	2025	831.67%
Quantum BioPharma (QNTM)	2025	821.05%
Oncology Institute (TOI)	2025	681.05%
Circle Internet (CRCL)	2025	675.1%
Oncology Institute (TOIIW)	2025	632.14%
Protagenic Therapeutics (PTIXW)	2025	567.69%
Webull Corporation Warrants (BULLW)	2025	540.72%
Dave Inc Warrants (DAVEW)	2025	537.1%
Dominari (DOMH)	2025	504.23%
ThredUp (TDUP)	2025	503.47%
Global Interactive Technologies (GITS)	2025	501.66%
Aeva Technologies, Inc Warrants (AEVAW)	2025	497.4%