MicroStrategy (MSTR) had the lowest return in April 2024 by a large-cap US stock, returning -35.3%.

ASSET	MONTH	% RETURN
MicroStrategy (MSTR)	April 2024	-35.26%
Globe Life (GL)	April 2024	-34.21%
Intel (INTC)	April 2024	-31.2%
Wayfair (W)	April 2024	-25.48%
Nextracker Inc Class A Common Stock (NXT)	April 2024	-25.24%
Ast Spacemobile (ASTS)	April 2024	-24.57%
Madrigal Pharmaceuticals (MDGL)	April 2024	-23.67%
IREN (IREN)	April 2024	-22.5%
Burlington Stores (BURL)	April 2024	-22.29%
Ulta Beauty (ULTA)	April 2024	-22.27%
Coinbase Global (COIN)	April 2024	-22.13%
Arm Holdings plc American Depositary Shares (ARM)	April 2024	-19.9%
Five Below (FIVE)	April 2024	-19.84%
Elanco Animal Health (ELAN)	April 2024	-19.31%
Rivian Automotive (RIVN)	April 2024	-19.02%
Franklin Resources (BEN)	April 2024	-18.6%
Autodesk (ADSK)	April 2024	-18.1%
Bristol-Myers Squibb (BMY)	April 2024	-17.94%
Equifax (EFX)	April 2024	-17.83%
Manhattan Associates (MANH)	April 2024	-17.66%
Robinhood Markets (HOOD)	April 2024	-17.47%
JB Hunt Transport Services (JBHT)	April 2024	-17.46%
BridgeBio Pharma (BBIO)	April 2024	-17.33%
Old Dominion Freight Line (ODFL)	April 2024	-17.25%
MSCI (MSCI)	April 2024	-17.17%

Large-cap stocks are treated as having a market cap of $10B+.