MakeMyTrip (MMYT) had the lowest return in Q4 2010 by a large-cap US stock, returning -30.3%.

ASSET	QUARTER	% RETURN
MakeMyTrip (MMYT)	Q4 2010	-30.26%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	Q4 2010	-21.29%
Alnylam Pharmaceuticals (ALNY)	Q4 2010	-19.71%
EXACT Sciences (EXAS)	Q4 2010	-18.31%
Natwest (NWG)	Q4 2010	-17.87%
Best Buy (BBY)	Q4 2010	-16.14%
Trip Group Ltd ADR (TCOM)	Q4 2010	-15.73%
PulteGroup (PHM)	Q4 2010	-15.12%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	Q4 2010	-14.96%
Banco Santander SA ADR (SAN)	Q4 2010	-14.67%
Builders FirstSource (BLDR)	Q4 2010	-14.35%
Fidelity National Financial (FNF)	Q4 2010	-13.91%
Barclays PLC ADR (BCS)	Q4 2010	-13.1%
First Solar (FSLR)	Q4 2010	-12.63%
Insmed (INSM)	Q4 2010	-12.39%
Expedia (EXPE)	Q4 2010	-12.19%
Lloyds Banking Group PLC ADR (LYG)	Q4 2010	-12.18%
HDFC Bank Limited ADR (HDB)	Q4 2010	-10.53%
Intuitive Surgical (ISRG)	Q4 2010	-10.04%
AstraZeneca PLC ADR (AZN)	Q4 2010	-9.7%
Texas Pacific Land Trust (TPL)	Q4 2010	-9.39%
NetEase (NTES)	Q4 2010	-9.19%
MercadoLibre (MELI)	Q4 2010	-8.74%
Cisco Systems (CSCO)	Q4 2010	-8.54%
Fresenius Medical Care (FMS)	Q4 2010	-8.15%

Large-cap stocks are treated as having a market cap of $10B+.