Coinbase Global (COIN) had the lowest return between 2010 and 2022 by a US stock in the S&P 500 (GSPC), returning -90.7%.

ASSET	YEARS	% RETURN
Coinbase Global (COIN)	2010-2022	-90.71%
Howmet Aerospace (HWM)	2010-2022	-86.66%
Carnival (CCL)	2010-2022	-66.51%
DoorDash, Inc Class A Common Stock (DASH)	2010-2022	-52.14%
PG&E (PCG)	2010-2022	-51.29%
Norwegian Cruise Line (NCLH)	2010-2022	-51.24%
APA (APA)	2010-2022	-45.92%
Marathon Petroleum (MPC)	2010-2022	-45.65%
Airbnb (ABNB)	2010-2022	-41.44%
Uber Technologies (UBER)	2010-2022	-41.12%
Warner Bros Discovery (WBD)	2010-2022	-39.59%
Palantir Technologies Inc Class A Common Stock (PLTR)	2010-2022	-35.8%
Viatris (VTRS)	2010-2022	-35.33%
Fox Corp Class B (FOX)	2010-2022	-22.05%
Fox Corp Class A (FOXA)	2010-2022	-15.66%
Mosaic (MOS)	2010-2022	-12.11%
Western Digital (WDC)	2010-2022	-11.02%
GE HealthCare Technologies (GEHC)	2010-2022	-7.33%
GE Aerospace (GE)	2010-2022	-2.68%
Kinder Morgan (KMI)	2010-2022	-1.55%
Schlumberger (SLB)	2010-2022	9.53%
First Solar (FSLR)	2010-2022	10.14%
Devon Energy (DVN)	2010-2022	12.92%
Franklin Resources (BEN)	2010-2022	15.24%
Dow (DOW)	2010-2022	16.61%