BitMine Immersion Technologies (BMNR) had the lowest return in 2021 by a US stock, returning -100%.

ASSET	YEAR	% RETURN
BitMine Immersion Technologies (BMNR)	2021	-99.99%
SS Innovations International Inc Common Stock (SSII)	2021	-99.81%
Synergy CHC Corp Common Stock (SNYR)	2021	-98.01%
17 Education Technology (YQ)	2021	-97.61%
Sentage (SNTG)	2021	-97.14%
Jiuzi (JZXN)	2021	-96.86%
Gaotu Techedu Inc DRC (GOTU)	2021	-96.23%
51Talk Online Education (COE)	2021	-95.55%
TAL Education (TAL)	2021	-94.51%
Forte Biosciences (FBRX)	2021	-94.26%
Fangdd Network (DUO)	2021	-93.88%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2021	-93.83%
Meiwu Technology (WNW)	2021	-93.72%
CalciMedica, Inc Common Stock (CALC)	2021	-93.7%
Alzamend Neuro (ALZN)	2021	-93.45%
Hycroft Mining (HYMCL)	2021	-92.5%
Hycroft Mining (HYMC)	2021	-92.23%
Naas Technology Inc ADR (NAAS)	2021	-91.9%
Momentus (MNTSW)	2021	-90.93%
Alset Ehome International (AEI)	2021	-90.7%
Motorsport Gaming Us LLC (MSGM)	2021	-90.29%
Team (TISI)	2021	-90.08%
Ontrak (OTRK)	2021	-90.05%
Tian Ruixiang (TIRX)	2021	-89.85%
Enliven Therapeutics (ELVN)	2021	-89.8%