Genmab A-S (GMAB) had the highest return between 2013 and 2015 by a large-cap US stock, returning 857.3%.

ASSET	YEARS	% RETURN
Genmab A-S (GMAB)	2013-2015	857.29%
Netflix (NFLX)	2013-2015	740.97%
Neurocrine Biosciences (NBIX)	2013-2015	636.59%
Tesla (TSLA)	2013-2015	585.75%
Incyte (INCY)	2013-2015	548.62%
DexCom (DXCM)	2013-2015	489.63%
Alnylam Pharmaceuticals (ALNY)	2013-2015	396.78%
Broadcom (AVGO)	2013-2015	370.2%
Globalstar, Inc Common Stock (GSAT)	2013-2015	350%
NetEase (NTES)	2013-2015	345.99%
Delta Air Lines (DAL)	2013-2015	329.69%
Manhattan Associates (MANH)	2013-2015	326.7%
Southwest Airlines (LUV)	2013-2015	321.58%
Constellation Brands Inc Class A (STZ)	2013-2015	299.2%
Trip Group Ltd ADR (TCOM)	2013-2015	294.3%
Facebook (META)	2013-2015	281.41%
Skyworks Solutions (SWKS)	2013-2015	271.09%
Tyler Technologies (TYL)	2013-2015	252.87%
Diamondback Energy (FANG)	2013-2015	243.78%
Illumina (ILMN)	2013-2015	242.16%
Kroger (KR)	2013-2015	231.47%
Interactive Brokers (IBKR)	2013-2015	229.22%
Corcept Therapeutics (CORT)	2013-2015	227.63%
Palo Alto Networks (PANW)	2013-2015	223.08%
Centene (CNC)	2013-2015	214.73%

Large-cap stocks are treated as having a market cap of $10B+.