InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2003 by a large-cap US stock, returning 5,813,300%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2003	5,813,300%
Ovintiv (OVV)	2000-2003	5,758.49%
NVR (NVR)	2000-2003	875.92%
Tractor Supply (TSCO)	2000-2003	870.35%
Hudbay Minerals (HBM)	2000-2003	822.83%
Chunghwa Telecom (CHT)	2000-2003	728.91%
Deckers Outdoor (DECK)	2000-2003	681.14%
Tapestry (TPR)	2000-2003	655%
Lennar (LEN)	2000-2003	633.31%
Clean Harbors (CLH)	2000-2003	631.05%
Royal Gold (RGLD)	2000-2003	502.66%
DR Horton (DHI)	2000-2003	491.82%
Hecla Mining (HL)	2000-2003	410.15%
East West Bancorp (EWBC)	2000-2003	403.97%
Old Dominion Freight Line (ODFL)	2000-2003	375.49%
Quest Diagnostics (DGX)	2000-2003	374.55%
HF Sinclair (DINO)	2000-2003	358.61%
UnitedHealth (UNH)	2000-2003	338.85%
CACI International (CACI)	2000-2003	329.79%
Toll Brothers (TOL)	2000-2003	326.96%
PulteGroup (PHM)	2000-2003	323.34%
Cameco (CCJ)	2000-2003	314.6%
Gilead Sciences (GILD)	2000-2003	308.1%
Laboratory Corporation of America (LH)	2000-2003	300.78%
Dick’s Sporting Goods (DKS)	2000-2003	297.23%

Large-cap stocks are treated as having a market cap of $10B+.