Zivo Bioscience (ZIVO) had the highest return between 2000 and 2003 by a US stock, returning 22,588,135.3%.

ASSET	YEARS	% RETURN
Zivo Bioscience (ZIVO)	2000-2003	22,588,135.29%
Hirequest (HQI)	2000-2003	5,793,250%
Houston American Energy (HUSA)	2000-2003	182,369.65%
ImmunoPrecise Antibodies (HYFT)	2000-2003	122,042.86%
Inseego (INSG)	2000-2003	99,733.33%
DeFi Technologies (DEFT)	2000-2003	32,900%
Interlink Electronics (LINK)	2000-2003	10,752.17%
Americas Silver (USAS)	2000-2003	8,347.37%
Gladstone Capital (GLAD)	2000-2003	4,354.28%
Flexible Solutions International (FSI)	2000-2003	4,032.97%
MEDIFAST (MED)	2000-2003	4,000.5%
China Yuchai International (CYD)	2000-2003	3,505.67%
Xcel Brands (XELB)	2000-2003	3,400%
Odyssey Marine Exploration (OMEX)	2000-2003	1,900%
American Vanguard (AVD)	2000-2003	1,526.47%
Yunhong Green CTI (YHGJ)	2000-2003	1,375.92%
Hovnanian Enterprises (HOV)	2000-2003	1,279.17%
CarMax (KMX)	2000-2003	1,274.67%
John B Sanfilippo & Son (JBSS)	2000-2003	1,176.02%
Avadel Pharmaceuticals (AVDL)	2000-2003	1,160.71%
USANA Health Sciences (USNA)	2000-2003	1,159.47%
BJs Restaurants (BJRI)	2000-2003	1,156.47%
Meritage (MTH)	2000-2003	1,133.71%
Axon Enterprise (AXON)	2000-2003	1,076.79%
SunOpta (STKL)	2000-2003	1,036%