QXO (QXO) had the highest return between 2010 and 2013 by a US stock with a market cap of $2B+, returning 2,352,000%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2013	2,352,000%
Ferguson (FERG)	2010-2013	138,387.03%
ACADIA Pharmaceuticals (ACAD)	2010-2013	1,793.18%
Cheniere Energy (LNG)	2010-2013	1,624.8%
Jazz Pharmaceuticals (JAZZ)	2010-2013	1,470.22%
Nexstar Broadcasting (NXST)	2010-2013	1,301.88%
Vipshop (VIPS)	2010-2013	1,294.64%
Patrick Industries (PATK)	2010-2013	1,076%
Regeneron Pharmaceuticals (REGN)	2010-2013	1,035.48%
Melco Resorts & Entertainment (MLCO)	2010-2013	1,030.24%
Domino's Pizza Inc Common Stock (DPZ)	2010-2013	794.16%
Lithia Motors (LAD)	2010-2013	785.4%
Bausch Health Companies (BHC)	2010-2013	785.27%
HCI (HCI)	2010-2013	726.48%
Tesla (TSLA)	2010-2013	691.71%
United Rentals (URI)	2010-2013	685.79%
Axos Financial (AX)	2010-2013	684.3%
CVR Energy (CVI)	2010-2013	682.12%
Dorman Products (DORM)	2010-2013	637.24%
Polaris Industries (PII)	2010-2013	617.59%
Netflix (NFLX)	2010-2013	563.13%
Generac (GNRC)	2010-2013	561.22%
Under Armour Inc A (UAA)	2010-2013	535.6%
Western Alliance Bancorporation (WAL)	2010-2013	513.37%
Tractor Supply (TSCO)	2010-2013	501.9%