AngloGold Ashanti (AU) had the highest return between 1998 and 2002 by a large-cap US stock, returning 12,410,900%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2002	12,410,900%
NVR (NVR)	1998-2002	1,392.57%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2002	1,344.71%
Clean Harbors (CLH)	1998-2002	822.02%
Harmony Gold Mining (HMY)	1998-2002	744.29%
eBay (EBAY)	1998-2002	660.64%
Quest Diagnostics (DGX)	1998-2002	574.38%
Eldorado Gold (EGO)	1998-2002	534.87%
Ryanair Holdings PLC ADR (RYAAY)	1998-2002	526.52%
Qualcomm (QCOM)	1998-2002	494.08%
Royal Gold (RGLD)	1998-2002	492.13%
Biogen (BIIB)	1998-2002	478.96%
Neurocrine Biosciences (NBIX)	1998-2002	470.75%
Laboratory Corporation of America (LH)	1998-2002	431.3%
Tractor Supply (TSCO)	1998-2002	428.08%
Brown & Brown (BRO)	1998-2002	359.46%
Take-Two Interactive Software (TTWO)	1998-2002	358.33%
Hudbay Minerals (HBM)	1998-2002	350.03%
ResMed (RMD)	1998-2002	332.84%
Logitech International (LOGI)	1998-2002	310.2%
Copart (CPRT)	1998-2002	305.92%
Infosys Ltd ADR (INFY)	1998-2002	302.45%
SEI Investments (SEIC)	1998-2002	293.66%
Best Buy (BBY)	1998-2002	292.29%
East West Bancorp (EWBC)	1998-2002	287.7%

Large-cap stocks are treated as having a market cap of $10B+.