NVIDIA (NVDA) had the highest return between 2014 and 2017 by a large-cap US stock, returning 1,174.8%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2014-2017	1,174.84%
Neurocrine Biosciences (NBIX)	2014-2017	737%
Take-Two Interactive Software (TTWO)	2014-2017	535.67%
Tower Semiconductor (TSEM)	2014-2017	484.56%
Corcept Therapeutics (CORT)	2014-2017	460.87%
Broadcom (AVGO)	2014-2017	417.3%
Exelixis (EXEL)	2014-2017	394.31%
Huazhu (HTHT)	2014-2017	386.6%
NetEase (NTES)	2014-2017	373.4%
Texas Pacific Land (TPL)	2014-2017	353.83%
Arista Networks (ANET)	2014-2017	326.39%
Genmab A-S (GMAB)	2014-2017	313.16%
Dycom Industries (DY)	2014-2017	303.73%
Align Technology (ALGN)	2014-2017	289.4%
Burlington Stores (BURL)	2014-2017	284.47%
Netflix (NFLX)	2014-2017	266.33%
Southwest Airlines (LUV)	2014-2017	258.29%
Lam Research (LRCX)	2014-2017	257.61%
argenx NV ADR (ARGX)	2014-2017	252.74%
NVR (NVR)	2014-2017	252.58%
Skyworks Solutions (SWKS)	2014-2017	250.73%
XPO Logistics (XPO)	2014-2017	248.38%
Edwards Lifesciences (EW)	2014-2017	243.21%
Centene (CNC)	2014-2017	242.2%
Monolithic Power Systems (MPWR)	2014-2017	240.4%

Large-cap stocks are treated as having a market cap of $10B+.