best large-cap performing stocks from 2010 to 2022

QXO (QXO) had the highest return between 2010 and 2022 by a large-cap US stock, returning 4,685,225%.

ASSET YEARS % RETURN
QXO (QXO)
2010-2022
4,685,225%
Ferguson (FERG)
2010-2022
839,688.19%
Tesla (TSLA)
2010-2022
9,624.48%
Texas Pacific Land Trust (TPL)
2010-2022
8,662.55%
Cheniere Energy (LNG)
2010-2022
5,975.72%
DexCom (DXCM)
2010-2022
5,417.17%
Domino's Pizza Inc Common Stock (DPZ)
2010-2022
4,773.81%
Neurocrine Biosciences (NBIX)
2010-2022
4,211.91%
Broadcom (AVGO)
2010-2022
3,989.23%
Axon Enterprise (AXON)
2010-2022
3,620.4%
Netflix (NFLX)
2010-2022
3,617.88%
United Rentals (URI)
2010-2022
3,482.87%
NVIDIA (NVDA)
2010-2022
3,341.27%
Old Dominion Freight Line (ODFL)
2010-2022
3,100.83%
Regeneron Pharmaceuticals (REGN)
2010-2022
2,876.43%
Fair Isaac (FICO)
2010-2022
2,736.33%
Fortinet (FTNT)
2010-2022
2,634.34%
Cadence Design Systems (CDNS)
2010-2022
2,572.88%
Ensign (ENSG)
2010-2022
2,526.18%
Transdigm (TDG)
2010-2022
2,502.84%
Genmab A-S (GMAB)
2010-2022
2,437.72%
Ulta Beauty (ULTA)
2010-2022
2,366.56%
Vipshop (VIPS)
2010-2022
2,173.31%
HEICO (HEI.A)
2010-2022
2,081.27%
O’Reilly Automotive (ORLY)
2010-2022
2,050.62%
Large-cap stocks are treated as having a market cap of $10B+.