BioNTech SE (BNTX) had the highest return in April 2021 by a large-cap US stock, returning 70.4%.

ASSET	MONTH	% RETURN
BioNTech SE (BNTX)	April 2021	70.37%
Galaxy Digital (GLXY)	April 2021	36.6%
Moderna (MRNA)	April 2021	35.26%
Equifax (EFX)	April 2021	26.46%
Viper Energy Ut (VNOM)	April 2021	22.77%
IQVIA (IQV)	April 2021	20.34%
Seagate Technology (STX)	April 2021	20.17%
United Parcel Service (UPS)	April 2021	19.79%
Imperial Oil (IMO)	April 2021	19.63%
Okta (OKTA)	April 2021	19.34%
Blackstone (BX)	April 2021	18.62%
Halozyme Therapeutics (HALO)	April 2021	18.17%
Nokia (NOK)	April 2021	17%
Avery Dennison (AVY)	April 2021	16.67%
TFI International (TFII)	April 2021	16.42%
Carlisle Companies (CSL)	April 2021	16.21%
Madrigal Pharmaceuticals (MDGL)	April 2021	16.2%
Capital One Financial (COF)	April 2021	16.1%
Brown & Brown (BRO)	April 2021	16.09%
Deutsche Bank (DB)	April 2021	16.09%
Arthur J Gallagher (AJG)	April 2021	16.04%
Apollo Global Management LLC Class A (APO)	April 2021	16.01%
Cloudflare (NET)	April 2021	15.81%
West Pharmaceutical Services (WST)	April 2021	15.75%
Vale SA ADR (VALE)	April 2021	15.7%

Large-cap stocks are treated as having a market cap of $10B+.