AngloGold Ashanti (AU) had the highest return between 1993 and 2003 by a large-cap US stock, returning 18,387,050%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1993-2003	18,387,050%
InterContinental Hotels Group PLC ADR (IHG)	1993-2003	5,929,900%
Suncor Energy (SU)	1993-2003	90,787.65%
Microchip Technology (MCHP)	1993-2003	5,034.6%
Coherent (COHR)	1993-2003	3,831.78%
Qualcomm (QCOM)	1993-2003	3,645.3%
Hubbell (HUBB)	1993-2003	3,590.66%
NVR (NVR)	1993-2003	3,006.67%
Jabil Circuit (JBL)	1993-2003	2,918.61%
Cognizant Technology Solutions Corp Class A (CTSH)	1993-2003	2,638.49%
Cooper Companies (COO)	1993-2003	2,439.98%
Johnson Controls International (JCI)	1993-2003	2,380.5%
Williams-Sonoma (WSM)	1993-2003	2,354.5%
Best Buy (BBY)	1993-2003	2,323.57%
Biogen (BIIB)	1993-2003	2,280.49%
Pool (POOL)	1993-2003	2,263.51%
CACI International (CACI)	1993-2003	2,154.79%
Tractor Supply (TSCO)	1993-2003	2,127.4%
Cisco Systems (CSCO)	1993-2003	2,115.41%
Expeditors International of Washington (EXPD)	1993-2003	2,089.28%
Amazon (AMZN)	1993-2003	2,058.33%
Applied Materials (AMAT)	1993-2003	2,012.06%
KLA-Tencor (KLAC)	1993-2003	1,892.76%
Paychex (PAYX)	1993-2003	1,886.21%
Lowe's Companies (LOW)	1993-2003	1,823.58%

Large-cap stocks are treated as having a market cap of $10B+.