InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2006 by a US stock with a market cap of $2B+, returning 16,461,200%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2006	16,461,200%
National Grid PLC ADR (NGG)	2003-2006	1,428,843.75%
Monster Beverage (MNST)	2003-2006	6,293.39%
Denison Mines (DNN)	2003-2006	4,690.59%
Cheniere Energy (LNG)	2003-2006	4,341.49%
Akamai Technologies (AKAM)	2003-2006	2,851.11%
Hub (HUBG)	2003-2006	2,186.3%
Axon Enterprise (AXON)	2003-2006	2,154.81%
ArcelorMittal SA ADR (MT)	2003-2006	2,015.34%
U-Haul (UHAL)	2003-2006	1,857.28%
BlackBerry (BB)	2003-2006	1,840.47%
Williams Companies (WMB)	2003-2006	1,769.17%
Deckers Outdoor (DECK)	2003-2006	1,711.09%
Grupo Simec SAB de CV ADR (SIM)	2003-2006	1,496.64%
Grupo Cibest (CIB)	2003-2006	1,496.32%
Allegheny Technologies (ATI)	2003-2006	1,493.67%
Stonex (SNEX)	2003-2006	1,460.28%
Banco Bradesco SA ADR (BBD)	2003-2006	1,446.85%
Frontline (FRO)	2003-2006	1,368.31%
Tenaris SA ADR (TS)	2003-2006	1,365.42%
Companhia Siderurgica Nacional ADR (SID)	2003-2006	1,276.92%
Gerdau SA ADR (GGB)	2003-2006	1,233.13%
Camtek (CAMT)	2003-2006	1,231.09%
BRF SA ADR (BRFS)	2003-2006	1,212.1%
Sterling Construction (STRL)	2003-2006	1,143.43%