InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2010 by a US stock, returning 14,004,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2010	14,004,900%
Northern Oil & Gas (NOG)	2000-2010	8,777,303.85%
QVC (QVCGA)	2000-2010	8,177,603.7%
Cemtrex (CETX)	2000-2010	4,938,903.31%
Know Labs (KNW)	2000-2010	4,885,152.16%
Houston American Energy (HUSA)	2000-2010	4,701,043.45%
Hirequest (HQI)	2000-2010	2,146,250%
National Grid PLC ADR (NGG)	2000-2010	1,128,370.59%
India Globalization Capital (IGC)	2000-2010	966,566.67%
Natwest (NWG)	2000-2010	774,270%
Ferguson (FERG)	2000-2010	431,485.11%
Perspective Therapeutics (CATX)	2000-2010	376,566.67%
Aris Mining (ARMN)	2000-2010	326,680.13%
Ring Energy (REI)	2000-2010	133,233.33%
First Majestic Silver (AG)	2000-2010	63,584%
Ocean Power Technologies (OPTT)	2000-2010	63,455.56%
Gyre Therapeutics (GYRE)	2000-2010	56,089.27%
Gulf Resources (GURE)	2000-2010	53,350%
Pioneer Power Solutions (PPSI)	2000-2010	29,429.23%
OPTIMIZERx (OPRX)	2000-2010	24,500%
Future Fintech (FTFT)	2000-2010	23,150%
NanoViricides (NNVC)	2000-2010	20,480%
Companhia Siderurgica Nacional ADR (SID)	2000-2010	13,662.3%
ImmunoPrecise Antibodies (HYFT)	2000-2010	11,900%
Monster Beverage (MNST)	2000-2010	9,668.39%