InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1992 and 2010 by a large-cap US stock, returning 14,004,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1992-2010	14,004,900%
AngloGold Ashanti (AU)	1992-2010	10,366,025%
National Grid PLC ADR (NGG)	1992-2010	1,128,370.59%
Natwest (NWG)	1992-2010	774,270%
Ferguson (FERG)	1992-2010	699,365.52%
Suncor Energy (SU)	1992-2010	653,708.33%
Royal Gold (RGLD)	1992-2010	192,941.95%
Monster Beverage (MNST)	1992-2010	18,439.15%
Cognizant Technology Solutions Corp Class A (CTSH)	1992-2010	17,490.3%
Altria (MO)	1992-2010	13,868.34%
Coherent (COHR)	1992-2010	12,261.72%
Oracle (ORCL)	1992-2010	8,778.49%
Hubbell (HUBB)	1992-2010	8,155.5%
Amazon (AMZN)	1992-2010	7,283.1%
Qualcomm (QCOM)	1992-2010	7,255.92%
Expeditors International of Washington (EXPD)	1992-2010	6,853.01%
Microchip Technology (MCHP)	1992-2010	6,599.16%
Jack Henry & Associates (JKHY)	1992-2010	5,966.21%
Best Buy (BBY)	1992-2010	5,912.8%
Tractor Supply (TSCO)	1992-2010	5,485.81%
Ross Stores (ROST)	1992-2010	5,446.77%
Coca-Cola Consolidated (COKE)	1992-2010	5,359.03%
Teva Pharma Industries Ltd ADR (TEVA)	1992-2010	5,015.86%
Southern Copper (SCCO)	1992-2010	4,813.8%
Starbucks (SBUX)	1992-2010	4,794.66%

Large-cap stocks are treated as having a market cap of $10B+.