InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2006 by a large-cap US stock, returning 16,461,200%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2006	16,461,200%
National Grid PLC ADR (NGG)	1999-2006	1,344,788.24%
Monster Beverage (MNST)	1999-2006	4,920.93%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2006	3,898.57%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2006	2,923.5%
Clean Harbors (CLH)	1999-2006	2,879.08%
Deckers Outdoor (DECK)	1999-2006	2,720.15%
Laboratory Corporation of America (LH)	1999-2006	2,037.48%
Logitech International (LOGI)	1999-2006	1,806.79%
Southern Copper (SCCO)	1999-2006	1,638.67%
Tapestry (TPR)	1999-2006	1,618.37%
Tenaris SA ADR (TS)	1999-2006	1,615.55%
Cheniere Energy (LNG)	1999-2006	1,540.37%
Sterling Construction (STRL)	1999-2006	1,482.55%
Cameco (CCJ)	1999-2006	1,386.94%
Ambev SA ADR (ABEV)	1999-2006	1,336.7%
NVIDIA (NVDA)	1999-2006	1,310.22%
Coherent (COHR)	1999-2006	1,296.98%
NVR (NVR)	1999-2006	1,252.56%
CME (CME)	1999-2006	1,248.04%
Pool (POOL)	1999-2006	1,246.01%
Infosys Ltd ADR (INFY)	1999-2006	1,217.24%
Axon Enterprise (AXON)	1999-2006	1,204.65%
Gilead Sciences (GILD)	1999-2006	1,166.96%
Quest Diagnostics (DGX)	1999-2006	1,119.91%

Large-cap stocks are treated as having a market cap of $10B+.