InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2004 by a large-cap US stock, returning 8,020,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2004	8,020,800%
Insmed (INSM)	1999-2004	52,032.7%
Axon Enterprise (AXON)	1999-2004	5,326.02%
Deckers Outdoor (DECK)	1999-2004	2,110.5%
Cheniere Energy (LNG)	1999-2004	1,709.69%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2004	1,558.69%
NVR (NVR)	1999-2004	1,513.42%
Laboratory Corporation of America (LH)	1999-2004	1,349.42%
Qualcomm (QCOM)	1999-2004	1,209.92%
Tapestry (TPR)	1999-2004	1,027.98%
Quest Diagnostics (DGX)	1999-2004	984.58%
Pool (POOL)	1999-2004	975.34%
Coherent (COHR)	1999-2004	962.24%
Logitech International (LOGI)	1999-2004	912.06%
Genesis Healthcare (GEN)	1999-2004	858.52%
Chunghwa Telecom (CHT)	1999-2004	845.27%
Clean Harbors (CLH)	1999-2004	828.62%
East West Bancorp (EWBC)	1999-2004	782.69%
Biogen (BIIB)	1999-2004	749.21%
Infosys Ltd ADR (INFY)	1999-2004	721.27%
CACI International (CACI)	1999-2004	710.46%
UnitedHealth (UNH)	1999-2004	707.14%
Ambev SA ADR (ABEV)	1999-2004	678.79%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2004	633.89%
Neurocrine Biosciences (NBIX)	1999-2004	604.29%

Large-cap stocks are treated as having a market cap of $10B+.