InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2005 by a large-cap US stock, returning 9,399,400%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2005	9,399,400%
National Grid PLC ADR (NGG)	2002-2005	1,050,078.57%
Cheniere Energy (LNG)	2002-2005	7,735.1%
NetEase (NTES)	2002-2005	7,392.54%
Monster Beverage (MNST)	2002-2005	3,614.71%
Grupo Cibest (CIB)	2002-2005	2,105.47%
ArcelorMittal SA ADR (MT)	2002-2005	1,374.85%
Banco Bradesco SA ADR (BBD)	2002-2005	1,106.03%
Sterling Construction (STRL)	2002-2005	884.21%
CME (CME)	2002-2005	866.5%
Chunghwa Telecom (CHT)	2002-2005	786.56%
Canadian Natural Resources (CNQ)	2002-2005	765.18%
Clean Harbors (CLH)	2002-2005	760%
WESCO International (WCC)	2002-2005	754.59%
Hologic (HOLX)	2002-2005	715.48%
Cameco (CCJ)	2002-2005	703.01%
Tenaris SA ADR (TS)	2002-2005	678.9%
Crown (CCK)	2002-2005	665.86%
Vale SA ADR (VALE)	2002-2005	644.16%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2005	637.19%
Southern Copper (SCCO)	2002-2005	608.63%
Alamos Gold (AGI)	2002-2005	607.73%
Royal Gold (RGLD)	2002-2005	598.49%
Tapestry (TPR)	2002-2005	592.42%
Teck Resources Ltd Class B (TECK)	2002-2005	589.55%

Large-cap stocks are treated as having a market cap of $10B+.