National Grid PLC ADR (NGG) had the highest return between 2004 and 2009 by a large-cap US stock, returning 1,161,476.5%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2004-2009	1,161,476.47%
Monster Beverage (MNST)	2004-2009	3,548.8%
Banco Bradesco SA ADR (BBD)	2004-2009	1,878.49%
Apple (AAPL)	2004-2009	1,856.15%
Intuitive Surgical (ISRG)	2004-2009	1,674.44%
Booking (BKNG)	2004-2009	1,110.03%
Bancolombia SA ADR (CIB)	2004-2009	997.03%
Ambev SA ADR (ABEV)	2004-2009	949.81%
Vale SA ADR (VALE)	2004-2009	875.66%
Elbit Systems (ESLT)	2004-2009	776.25%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2009	771.67%
Trip Group Ltd ADR (TCOM)	2004-2009	764.09%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2009	752.61%
Illumina (ILMN)	2004-2009	740.55%
Suzano Papel e Celulose SA ADR (SUZ)	2004-2009	697.11%
Itau Unibanco Banco (ITUB)	2004-2009	689.15%
Tenaris SA ADR (TS)	2004-2009	645.75%
Credicorp (BAP)	2004-2009	602.15%
Clean Harbors (CLH)	2004-2009	570.53%
Southern Copper (SCCO)	2004-2009	553.57%
Mastercard (MA)	2004-2009	542.76%
Baidu (BIDU)	2004-2009	523.08%
Stifel Financial (SF)	2004-2009	520.33%
Alphabet Inc Class A (GOOGL)	2004-2009	519.93%
ArcelorMittal SA ADR (MT)	2004-2009	495.99%

Large-cap stocks are treated as having a market cap of $10B+.