National Grid PLC ADR (NGG) had the highest return between 2005 and 2011 by a large-cap US stock, returning 1,058,804.8%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2005-2011	1,058,804.76%
Natwest (NWG)	2005-2011	400,280%
Ferguson (FERG)	2005-2011	248,378.75%
Booking (BKNG)	2005-2011	1,871.8%
Monster Beverage (MNST)	2005-2011	1,871.32%
Baidu (BIDU)	2005-2011	1,664.7%
Apple (AAPL)	2005-2011	1,150.33%
Intuitive Surgical (ISRG)	2005-2011	1,056.96%
Mastercard (MA)	2005-2011	840.63%
Wheaton Precious Metals (WPM)	2005-2011	839.2%
CF Industries (CF)	2005-2011	817.59%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2005-2011	779.29%
Credicorp (BAP)	2005-2011	745.93%
Clean Harbors (CLH)	2005-2011	738.55%
Chipotle Mexican Grill (CMG)	2005-2011	650.53%
Ambev SA ADR (ABEV)	2005-2011	638.23%
Banco Bradesco SA ADR (BBD)	2005-2011	611.73%
TechnipFMC (FTI)	2005-2011	596.46%
Illumina (ILMN)	2005-2011	547.14%
Southern Copper (SCCO)	2005-2011	533.76%
Salesforce (CRM)	2005-2011	518.28%
Regeneron Pharmaceuticals (REGN)	2005-2011	492.2%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2005-2011	488.46%
Alamos Gold (AGI)	2005-2011	474.2%
Netflix (NFLX)	2005-2011	455.2%

Large-cap stocks are treated as having a market cap of $10B+.