QXO (QXO) had the highest return between 2012 and 2017 by a large-cap US stock, returning 9,913,100%.

ASSET	YEARS	% RETURN
QXO (QXO)	2012-2017	9,913,100%
Genmab A-S (GMAB)	2012-2017	2,434.56%
Netflix (NFLX)	2012-2017	1,811.95%
Alnylam Pharmaceuticals (ALNY)	2012-2017	1,425.21%
NVIDIA (NVDA)	2012-2017	1,359.41%
Texas Pacific Land (TPL)	2012-2017	1,035.2%
Constellation Brands Inc Class A (STZ)	2012-2017	1,021.23%
Tesla (TSLA)	2012-2017	975.87%
Huazhu (HTHT)	2012-2017	945.12%
Insmed (INSM)	2012-2017	899.36%
Broadcom (AVGO)	2012-2017	864.38%
IES (IESC)	2012-2017	845.41%
Align Technology (ALGN)	2012-2017	816.63%
Neurocrine Biosciences (NBIX)	2012-2017	787.76%
NetEase (NTES)	2012-2017	739.13%
Monolithic Power Systems (MPWR)	2012-2017	695.66%
Take-Two Interactive Software (TTWO)	2012-2017	693.78%
Huntington Ingalls Industries (HII)	2012-2017	684.97%
Southwest Airlines (LUV)	2012-2017	684.26%
NXP Semiconductors (NXPI)	2012-2017	642.01%
XPO Logistics (XPO)	2012-2017	632.72%
Burlington Stores (BURL)	2012-2017	623.71%
Delta Air Lines (DAL)	2012-2017	622.57%
Diamondback Energy (FANG)	2012-2017	608.47%
Illumina (ILMN)	2012-2017	604.81%

Large-cap stocks are treated as having a market cap of $10B+.