NVIDIA (NVDA) had the highest return between 2014 and 2016 by a large-cap US stock, returning 600.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2014-2016	600.51%
Neurocrine Biosciences (NBIX)	2014-2016	317.48%
Genmab A-S (GMAB)	2014-2016	313.33%
IES (IESC)	2014-2016	271.12%
Broadcom (AVGO)	2014-2016	249.08%
Electronic Arts (EA)	2014-2016	243.93%
Tower Semiconductor (TSEM)	2014-2016	226.42%
Silicon Motion Technology (SIMO)	2014-2016	221.26%
Texas Pacific Land (TPL)	2014-2016	200.2%
AXIA Energia (AXIA)	2014-2016	198.88%
Advanced Micro Devices (AMD)	2014-2016	194.55%
NetEase (NTES)	2014-2016	191.83%
Dycom Industries (DY)	2014-2016	190.91%
Take-Two Interactive Software (TTWO)	2014-2016	185.41%
Edwards Lifesciences (EW)	2014-2016	185.32%
Southwest Airlines (LUV)	2014-2016	170.62%
MACOM Technology Solutions (MTSI)	2014-2016	168.29%
Ulta Beauty (ULTA)	2014-2016	164.98%
Burlington Stores (BURL)	2014-2016	164.84%
Coca-Cola Consolidated (COKE)	2014-2016	151.99%
Monolithic Power Systems (MPWR)	2014-2016	146.26%
Exelixis (EXEL)	2014-2016	142.44%
Advanced Energy Industries (AEIS)	2014-2016	140.87%
Netflix (NFLX)	2014-2016	136.26%
Martin Marietta Materials (MLM)	2014-2016	129.83%

Large-cap stocks are treated as having a market cap of $10B+.