Celsius (CELH) had the highest return between 2016 and 2022 by a large-cap US stock, returning 5,262.6%.

ASSET	YEARS	% RETURN
Celsius (CELH)	2016-2022	5,262.61%
Madrigal Pharmaceuticals (MDGL)	2016-2022	2,412.99%
Advanced Micro Devices (AMD)	2016-2022	2,238.27%
argenx NV ADR (ARGX)	2016-2022	2,016.37%
Texas Pacific Land Trust (TPL)	2016-2022	1,934.86%
NVIDIA (NVDA)	2016-2022	1,753.66%
Trade Desk (TTD)	2016-2022	1,459.3%
Teck Resources Ltd Class B (TECK)	2016-2022	1,022.2%
Lattice Semiconductor (LSCC)	2016-2022	913.75%
Axon Enterprise (AXON)	2016-2022	876.06%
BioNTech SE (BNTX)	2016-2022	810.42%
Ubiquiti Networks (UI)	2016-2022	788.63%
Deckers Outdoor (DECK)	2016-2022	766.8%
Nova (NVMI)	2016-2022	730.08%
Moderna (MRNA)	2016-2022	716.45%
Vale SA ADR (VALE)	2016-2022	708.64%
Cadence Design Systems (CDNS)	2016-2022	703.2%
Tesla (TSLA)	2016-2022	700.84%
Fortinet (FTNT)	2016-2022	700.43%
Insulet (PODD)	2016-2022	691.37%
Medpace (MEDP)	2016-2022	671%
BeiGene (ONC)	2016-2022	659.2%
MercadoLibre (MELI)	2016-2022	658.11%
Old Dominion Freight Line (ODFL)	2016-2022	648.98%
Ares Management (ARES)	2016-2022	645.57%

Large-cap stocks are treated as having a market cap of $10B+.