Advanced Drainage Systems (WMS) had the highest return between 2018 and 2021 by a large-cap US stock when the return was < 510%, returning 506.9%.

ASSET	YEARS	% RETURN
Advanced Drainage Systems (WMS)	2018-2021	506.9%
NVIDIA (NVDA)	2018-2021	506.46%
Chipotle Mexican Grill (CMG)	2018-2021	500.98%
Medpace (MEDP)	2018-2021	496.11%
Axon Enterprise (AXON)	2018-2021	492.01%
Zebra Technologies (ZBRA)	2018-2021	471.76%
United Microelectronics (UMC)	2018-2021	465.67%
argenx NV ADR (ARGX)	2018-2021	451.65%
Tenet Healthcare (THC)	2018-2021	435.67%
Kinsale Capital (KNSL)	2018-2021	433.6%
Nio Inc Class A ADR (NIO)	2018-2021	423.64%
Paycom Soft (PAYC)	2018-2021	415.96%
Lululemon Athletica (LULU)	2018-2021	406.34%
MSCI (MSCI)	2018-2021	399.67%
ServiceNow (NOW)	2018-2021	395.5%
Amun Bitwise Select 10 Large Cap Crypto ETP (KEYS)	2018-2021	392.86%
Ares Management (ARES)	2018-2021	384.68%
Blackstone (BX)	2018-2021	382.09%
West Pharmaceutical Services (WST)	2018-2021	381.36%
ASML Holding NV ADR (ASML)	2018-2021	375.46%
Bilibili (BILI)	2018-2021	373.47%
Block (XYZ)	2018-2021	365.45%
Entegris (ENTG)	2018-2021	363.95%
Deckers Outdoor (DECK)	2018-2021	362.92%
Veeva Systems Inc Class A (VEEV)	2018-2021	361.82%

Large-cap stocks are treated as having a market cap of $10B+.