Permian Resources (PR) had the highest return between 2021 and 2022 by a large-cap US stock, returning 529.6%.

ASSET	YEARS	% RETURN
Permian Resources (PR)	2021-2022	529.6%
Antero Resources (AR)	2021-2022	456.37%
Dillard's (DDS)	2021-2022	455.16%
Devon Energy (DVN)	2021-2022	341.09%
Globalstar, Inc Common Stock (GSAT)	2021-2022	303.03%
Occidental Petroleum (OXY)	2021-2022	258.34%
Ovintiv (OVV)	2021-2022	255.65%
Texas Pacific Land (TPL)	2021-2022	233.07%
APA (APA)	2021-2022	226%
Cenovus Energy (CVE)	2021-2022	224.07%
ConocoPhillips (COP)	2021-2022	216.1%
Viper Energy Ut (VNOM)	2021-2022	211.39%
Diamondback Energy (FANG)	2021-2022	204.14%
Marathon Petroleum (MPC)	2021-2022	197.8%
Exxon Mobil (XOM)	2021-2022	193.75%
EOG Resources (EOG)	2021-2022	187.05%
Targa Resources (TRGP)	2021-2022	183.22%
Steel Dynamics (STLD)	2021-2022	168.76%
Imperial Oil (IMO)	2021-2022	168.66%
EQT (EQT)	2021-2022	165.08%
Canadian Natural Resources (CNQ)	2021-2022	159.36%
Madrigal Pharmaceuticals (MDGL)	2021-2022	158.9%
Super Micro Computer (SMCI)	2021-2022	158.18%
Nucor (NUE)	2021-2022	151.74%
Schlumberger (SLB)	2021-2022	150.03%

Large-cap stocks are treated as having a market cap of $10B+.