InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2008 by a large-cap US stock, returning 5,519,600%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2008	5,519,600%
National Grid PLC ADR (NGG)	2002-2008	1,237,321.43%
Natwest (NWG)	2002-2008	953,400%
NetEase (NTES)	2002-2008	11,694.24%
Monster Beverage (MNST)	2002-2008	6,221.72%
Grupo Cibest (CIB)	2002-2008	1,891.03%
Clean Harbors (CLH)	2002-2008	1,793.73%
Deckers Outdoor (DECK)	2002-2008	1,706.68%
Banco Bradesco SA ADR (BBD)	2002-2008	1,528.57%
ArcelorMittal SA ADR (MT)	2002-2008	1,467.99%
Southern Copper (SCCO)	2002-2008	1,214.1%
Chunghwa Telecom (CHT)	2002-2008	996.6%
Sterling Construction (STRL)	2002-2008	983.63%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2008	952.56%
Royal Gold (RGLD)	2002-2008	916.18%
Vale SA ADR (VALE)	2002-2008	834.5%
Alamos Gold (AGI)	2002-2008	774.41%
Stifel Financial (SF)	2002-2008	773.49%
Kinross Gold (KGC)	2002-2008	768.47%
Apple (AAPL)	2002-2008	673.84%
Crown (CCK)	2002-2008	652.92%
Tenaris SA ADR (TS)	2002-2008	650.84%
Old Dominion Freight Line (ODFL)	2002-2008	620.64%
Credicorp (BAP)	2002-2008	609.66%
Canadian Natural Resources (CNQ)	2002-2008	608.74%

Large-cap stocks are treated as having a market cap of $10B+.