NetEase (NTES) had the highest return between 2002 and 2008 by a large-cap US stock, returning 11,686.1%.

ASSET	YEARS	% RETURN
NetEase (NTES)	2002-2008	11,686.05%
Monster Beverage (MNST)	2002-2008	6,221.72%
Ovintiv (OVV)	2002-2008	2,372.71%
Grupo Cibest (CIB)	2002-2008	1,891.03%
Clean Harbors (CLH)	2002-2008	1,793.73%
Deckers Outdoor (DECK)	2002-2008	1,706.68%
ArcelorMittal SA ADR (MT)	2002-2008	1,556.43%
Southern Copper (SCCO)	2002-2008	1,213.92%
Chunghwa Telecom (CHT)	2002-2008	996.6%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2008	952.56%
Royal Gold (RGLD)	2002-2008	916.2%
Vale SA ADR (VALE)	2002-2008	834.42%
Alamos Gold (AGI)	2002-2008	774.31%
Stifel Financial (SF)	2002-2008	773.48%
Kinross Gold (KGC)	2002-2008	768.5%
Apple (AAPL)	2002-2008	674.02%
Crown (CCK)	2002-2008	652.92%
Tenaris SA ADR (TS)	2002-2008	650.85%
Old Dominion Freight Line (ODFL)	2002-2008	620.61%
Credicorp (BAP)	2002-2008	609.66%
Canadian Natural Resources (CNQ)	2002-2008	608.72%
Elbit Systems (ESLT)	2002-2008	586.44%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2002-2008	561.31%
Intuitive Surgical (ISRG)	2002-2008	547.87%
Gilead Sciences (GILD)	2002-2008	529.13%

Large-cap stocks are treated as having a market cap of $10B+.