InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2007 by a large-cap US stock, returning 10,940,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2007	10,940,800%
Hudbay Minerals (HBM)	2003-2007	24,434.06%
Monster Beverage (MNST)	2003-2007	8,307.29%
Expedia (EXPE)	2003-2007	7,721.78%
Cheniere Energy (LNG)	2003-2007	4,921.41%
Deckers Outdoor (DECK)	2003-2007	4,584.28%
Axon Enterprise (AXON)	2003-2007	4,163.7%
ArcelorMittal SA ADR (MT)	2003-2007	4,024.51%
Banco Bradesco SA ADR (BBD)	2003-2007	3,768.8%
Apple (AAPL)	2003-2007	2,659.23%
Intuitive Surgical (ISRG)	2003-2007	2,526.15%
Williams Companies (WMB)	2003-2007	2,490%
Vale SA ADR (VALE)	2003-2007	2,113.22%
Southern Copper (SCCO)	2003-2007	2,024.97%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2007	1,997.74%
Akamai Technologies (AKAM)	2003-2007	1,822.22%
Grupo Cibest (CIB)	2003-2007	1,704.59%
Illumina (ILMN)	2003-2007	1,637.79%
CME (CME)	2003-2007	1,530.01%
Allegheny Technologies (ATI)	2003-2007	1,427.08%
America Movil SAB de CV ADR (AMX)	2003-2007	1,273.91%
Tenaris SA ADR (TS)	2003-2007	1,237.47%
Itau Unibanco Banco (ITUB)	2003-2007	1,200.27%
GameStop (GME)	2003-2007	1,167.54%
Carpenter Technology (CRS)	2003-2007	1,166.79%

Large-cap stocks are treated as having a market cap of $10B+.