QXO (QXO) had the highest return between 2003 and 2012 by a large-cap US stock, returning 948,647.1%.

ASSET	YEARS	% RETURN
QXO (QXO)	2003-2012	948,647.06%
Monster Beverage (MNST)	2003-2012	19,960.82%
Expedia (EXPE)	2003-2012	10,539.74%
Apple (AAPL)	2003-2012	7,378.85%
Booking (BKNG)	2003-2012	6,282.65%
Banco Bradesco SA ADR (BBD)	2003-2012	4,869.14%
Ambev SA ADR (ABEV)	2003-2012	4,572.51%
Grupo Cibest (CIB)	2003-2012	4,018.93%
Intuitive Surgical (ISRG)	2003-2012	3,886.94%
Deckers Outdoor (DECK)	2003-2012	3,549.65%
Williams Companies (WMB)	2003-2012	3,221.81%
Illumina (ILMN)	2003-2012	3,160.33%
Southern Copper (SCCO)	2003-2012	3,055.01%
Cheniere Energy (LNG)	2003-2012	2,789.17%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2003-2012	2,552.67%
Axon Enterprise (AXON)	2003-2012	2,548.89%
Alamos Gold (AGI)	2003-2012	2,207.06%
Akamai Technologies (AKAM)	2003-2012	2,172.78%
HF Sinclair (DINO)	2003-2012	2,125.34%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2003-2012	2,107.3%
Chunghwa Telecom (CHT)	2003-2012	2,016.77%
Credicorp (BAP)	2003-2012	1,962.22%
Johnson Controls International (JCI)	2003-2012	1,908.85%
First Majestic Silver (AG)	2003-2012	1,752.33%
Cummins (CMI)	2003-2012	1,719.83%

Large-cap stocks are treated as having a market cap of $10B+.