Dollar Tree (DLTR) had the highest return between 2008 and 2008 by a large-cap US stock, returning 60.9%.

ASSET	YEARS	% RETURN
Dollar Tree (DLTR)	2008-2008	60.88%
Royal Gold (RGLD)	2008-2008	58.98%
AeroVironment (AVAV)	2008-2008	48.91%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2008	36.99%
Stifel Financial (SF)	2008-2008	31.53%
Vertex Pharmaceuticals (VRTX)	2008-2008	30.67%
YPF Sociedad Anonima (YPF)	2008-2008	25.91%
Old Dominion Freight Line (ODFL)	2008-2008	25.37%
Amgen (AMGN)	2008-2008	23.93%
Clean Harbors (CLH)	2008-2008	23.54%
Fidelity National Financial (FNF)	2008-2008	22.16%
Edwards Lifesciences (EW)	2008-2008	20.19%
Ensign (ENSG)	2008-2008	18.87%
Alamos Gold (AGI)	2008-2008	18.2%
Ross Stores (ROST)	2008-2008	18.1%
Hasbro (HAS)	2008-2008	17.11%
NetEase (NTES)	2008-2008	16.32%
AutoZone (AZO)	2008-2008	16.13%
Westinghouse Air Brake Technologies (WAB)	2008-2008	15.83%
MasTec (MTZ)	2008-2008	14.43%
Franco-Nevada (FNV)	2008-2008	14.36%
Watsco (WSO.B)	2008-2008	13.37%
Arthur J Gallagher (AJG)	2008-2008	12.9%
Netflix (NFLX)	2008-2008	12.55%
Gilead Sciences (GILD)	2008-2008	11.27%

Large-cap stocks are treated as having a market cap of $10B+.