Advanced Micro Devices (AMD) had the highest return between 2016 and 2019 by a large-cap US stock, returning 1,555.6%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2019	1,555.6%
EXACT Sciences (EXAS)	2016-2019	929.84%
Trade Desk (TTD)	2016-2019	803.58%
argenx NV ADR (ARGX)	2016-2019	796.76%
Roku (ROKU)	2016-2019	748.54%
Madrigal Pharmaceuticals (MDGL)	2016-2019	688.83%
Ascendis Pharma A-S (ASND)	2016-2019	670.32%
NVIDIA (NVDA)	2016-2019	643.56%
AXIA Energia (AXIA)	2016-2019	635.49%
Centrais Electricas Brasileiras (EBR)	2016-2019	631.5%
Carvana (CVNA)	2016-2019	581.85%
Texas Pacific Land Trust (TPL)	2016-2019	534.18%
Ubiquiti Networks (UI)	2016-2019	499.92%
BeiGene (ONC)	2016-2019	472.18%
SPX (SPXC)	2016-2019	451.84%
Burlington Stores (BURL)	2016-2019	445%
Huazhu (HTHT)	2016-2019	434.86%
MercadoLibre (MELI)	2016-2019	412.37%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2016-2019	399.34%
Veeva Systems Inc Class A (VEEV)	2016-2019	395.81%
Teck Resources Ltd Class B (TECK)	2016-2019	395.54%
Block (XYZ)	2016-2019	390.67%
Okta (OKTA)	2016-2019	389.69%
Copart (CPRT)	2016-2019	383.62%
Vale SA ADR (VALE)	2016-2019	367.46%

Large-cap stocks are treated as having a market cap of $10B+.