Celestica (CLS) had the highest return between 2022 and 2025 by a large-cap US stock, returning 2,553.6%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2022-2025	2,553.59%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2022-2025	1,834.47%
Credo Technology (CRDO)	2022-2025	1,089.17%
Sterling Infrastructure (STRL)	2022-2025	1,053.41%
Carpenter Technology (CRS)	2022-2025	1,022.2%
Palantir Technologies (PLTR)	2022-2025	868.14%
Constellation Energy (CEG)	2022-2025	861.45%
Comfort Systems USA (FIX)	2022-2025	855.24%
YPF Sociedad Anonima (YPF)	2022-2025	839.22%
Ast Spacemobile (ASTS)	2022-2025	805.61%
FTAI Aviation (FTAI)	2022-2025	805.03%
Vistra (VST)	2022-2025	661.36%
IES (IESC)	2022-2025	660.7%
TechnipFMC (FTI)	2022-2025	644.27%
Allegheny Technologies (ATI)	2022-2025	616.35%
Applovin (APP)	2022-2025	609.28%
Madrigal Pharmaceuticals (MDGL)	2022-2025	578.32%
Sandisk (SNDK)	2022-2025	577.07%
Reddit (RDDT)	2022-2025	576.09%
Summit Therapeutics (SMMT)	2022-2025	575.03%
Super Micro Computer (SMCI)	2022-2025	556.13%
Howmet Aerospace (HWM)	2022-2025	548.6%
Vertiv (VRT)	2022-2025	546.2%
Insmed (INSM)	2022-2025	531.95%
NVIDIA (NVDA)	2022-2025	526.74%

Large-cap stocks are treated as having a market cap of $10B+.