InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2008 by a US stock with a market cap of $2B+, returning 5,519,600%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2008	5,519,600%
Natwest (NWG)	2002-2008	953,400%
Northern Oil & Gas (NOG)	2002-2008	838,607.69%
NetEase (NTES)	2002-2008	11,694.24%
Monster Beverage (MNST)	2002-2008	6,221.72%
Companhia Siderurgica Nacional ADR (SID)	2002-2008	5,271.96%
Frontline (FRO)	2002-2008	1,909.9%
Grupo Cibest (CIB)	2002-2008	1,891.03%
Clean Harbors (CLH)	2002-2008	1,793.73%
Deckers Outdoor (DECK)	2002-2008	1,706.68%
Cal-Maine Foods (CALM)	2002-2008	1,627.8%
ArcelorMittal SA ADR (MT)	2002-2008	1,556.43%
Stonex (SNEX)	2002-2008	1,283.64%
Southern Copper (SCCO)	2002-2008	1,213.92%
Gerdau SA ADR (GGB)	2002-2008	1,070.42%
Cleveland-Cliffs (CLF)	2002-2008	1,061.09%
Banco Bradesco SA ADR (BBD)	2002-2008	1,054.7%
VSE (VSEC)	2002-2008	1,038.09%
Chunghwa Telecom (CHT)	2002-2008	996.6%
Sterling Construction (STRL)	2002-2008	983.63%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2008	952.56%
Hub (HUBG)	2002-2008	938.4%
BlackBerry (BB)	2002-2008	926.04%
Royal Gold (RGLD)	2002-2008	916.18%
Middleby (MIDD)	2002-2008	915.87%