Northern Oil & Gas (NOG) had the highest return between 2007 and 2008 by a US stock with a market cap of $2B+, returning 852,476.9%.

ASSET	YEARS	% RETURN
Northern Oil & Gas (NOG)	2007-2008	852,476.92%
MAG Silver (MAG)	2007-2008	91,404.17%
First Solar (FSLR)	2007-2008	357.28%
Cal-Maine Foods (CALM)	2007-2008	228.81%
VSE (VSEC)	2007-2008	127.12%
Adtalem Global Education (ATGE)	2007-2008	104.81%
Riot Blockchain (RIOT)	2007-2008	99.03%
CF Industries (CF)	2007-2008	90.95%
ICL Israel Chemicals (ICL)	2007-2008	90.07%
Perrigo (PRGO)	2007-2008	88.41%
Grand Canyon Education (LOPE)	2007-2008	87.8%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2007-2008	82.43%
Stifel Financial (SF)	2007-2008	79.1%
Argan (AGX)	2007-2008	67.95%
Booking (BKNG)	2007-2008	67.46%
American Superconductor (AMSC)	2007-2008	65.42%
New Oriental Education & Technology (EDU)	2007-2008	63.42%
Exponent (EXPO)	2007-2008	61.38%
Mosaic (MOS)	2007-2008	60.4%
FTI Consulting (FCN)	2007-2008	59.63%
Masimo (MASI)	2007-2008	57%
Gilead Sciences (GILD)	2007-2008	56.68%
Kinross Gold (KGC)	2007-2008	54.29%
Comstock Resources (CRK)	2007-2008	52.12%
Sapiens International (SPNS)	2007-2008	52.12%