QXO (QXO) had the highest return between 2010 and 2015 by a US stock with a market cap of $2B+, returning 3,068,850%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2015	3,068,850%
Inventrust Properties (IVT)	2010-2015	751,855%
Ferguson (FERG)	2010-2015	300,800%
ACADIA Pharmaceuticals (ACAD)	2010-2015	2,600.76%
Vipshop (VIPS)	2010-2015	2,444.97%
Regeneron Pharmaceuticals (REGN)	2010-2015	2,139.56%
Travere Therapeutics (TVTX)	2010-2015	2,043.33%
Neurocrine Biosciences (NBIX)	2010-2015	1,942.24%
Patrick Industries (PATK)	2010-2015	1,668.37%
Jazz Pharmaceuticals (JAZZ)	2010-2015	1,643.92%
Nexstar Broadcasting (NXST)	2010-2015	1,418.37%
Cheniere Energy (LNG)	2010-2015	1,390%
Domino's Pizza Inc Common Stock (DPZ)	2010-2015	1,363.14%
Netflix (NFLX)	2010-2015	1,342.12%
Acadia Healthcare (ACHC)	2010-2015	1,294.2%
Lithia Motors (LAD)	2010-2015	1,281.38%
Tesla (TSLA)	2010-2015	1,163.18%
Expedia (EXPE)	2010-2015	1,158.31%
Incyte (INCY)	2010-2015	1,076.25%
Under Armour Inc A (UAA)	2010-2015	1,073.79%
CleanSpark (CLSK)	2010-2015	1,053.86%
Manhattan Associates (MANH)	2010-2015	987.88%
Silicon Motion Technology (SIMO)	2010-2015	909.65%
DexCom (DXCM)	2010-2015	897.56%
Ulta Beauty (ULTA)	2010-2015	872.8%