Vor Biopharma (VOR) had the highest return in June 2025 by a small-cap US stock, returning 710%.

ASSET	MONTH	% RETURN
Vor Biopharma (VOR)	June 2025	710%
mF International Limited Ordinary Shares (MFI)	June 2025	494.12%
Newegg Commerce (NEGG)	June 2025	234.85%
Critical Metals Corp Ordinary Shares (CRML)	June 2025	157.55%
Phoenix Asia Holdings Limited Ordinary Shares (PHOE)	June 2025	154.83%
Digi Power X (DGXX)	June 2025	124.8%
Phathom Pharmaceuticals (PHAT)	June 2025	124.07%
Sagimet Biosciences Inc Series A Common Stock (SGMT)	June 2025	116.48%
Aeva Technologies, Inc Common Stock (AEVA)	June 2025	110.06%
Prime Medicine, Inc Common Stock (PRME)	June 2025	109.32%
Immuneering (IMRX)	June 2025	98.24%
Blacksky Technology (BKSY)	June 2025	82.29%
Arqit Quantum (ARQQ)	June 2025	76.33%
BTQ Technologies Corp Common Stock (BTQ)	June 2025	74.56%
Quantum Computing (QUBT)	June 2025	69.5%
BigBearai (BBAI)	June 2025	68.91%
Galectin Therapeutics (GALT)	June 2025	63.57%
Ginkgo Bioworks (DNA)	June 2025	61.41%
Paysign (PAYS)	June 2025	60.71%
Ascentage Pharma Group International (AAPG)	June 2025	60.06%
Unusual Machines (UMAC)	June 2025	56.1%
Rezolve AI Limited Ordinary Shares (RZLV)	June 2025	56.09%
Amprius Technologies (AMPX)	June 2025	55.35%
REalloys (ALOY)	June 2025	52.99%
Evolent Health (EVH)	June 2025	52.37%

Small-cap stocks are treated as having a market cap between $300M and $2B.